The rain screen system is a universal facade structure. However, it is necessary to choose an appropriate type of insulation considering the large temperature difference depending on the region. The object of the study is to establish the dependence between the thickness of thermal insulation layer and the regional features. It is considered different climatic conditions of regions to systematize possible types of material: from the subtropical to the arctic. This option is relevant for Russia, but it can be applied in other countries with the similar climate. Subarctic, temperate, subtropical are the climate zones cover the most developed cities, where it is possible to use rain screen system. In this study, the classification of types of thermal insulation is made for given regions taking into account their physical characteristics. Based on the work, it is possible to analyze the regions in terms of the "relevance" of the using materials, their durability and the reconstruction of existing structures. As a result of the study, the average and maximum values of the insulation thickness were determined depending on the climatic region. It has also been proved that double-layer thermal insulation is better than single-layer thermal properties.